Research progress on microRNA associated with chemoresistance of NHL.
10.7534/j.issn.1009-2137.2014.05.059
- Author:
Rong-Li ZHENG
1
;
Yu-Jie JIANG
1
;
Xin WANG
2
Author Information
1. Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, Shandong Province, China.
2. Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, Shandong Province, China. E-mail: xinw@sdu.edu.cn.
- Publication Type:Journal Article
- MeSH:
Animals;
Drug Resistance, Multiple;
Drug Resistance, Neoplasm;
Lymphoma, Non-Hodgkin;
drug therapy;
genetics;
MicroRNAs;
genetics
- From:
Journal of Experimental Hematology
2014;22(5):1490-1494
- CountryChina
- Language:Chinese
-
Abstract:
Non-Hodgkin's lymphoma (NHL) is a malignant tumor originated in lymphatic hematopoietic tissue. At present, chemotherapy is the main treatment method of NHL, but the chemoresistance is still an important reason for NHL treatment failure. The mechanism of NHL multidrug resistance (MDR) is complex, involving a variety of singnal pathways, in which mutation in the genetic level of the key genes can result in tumor cell resistance phenomenon. MicroRNA are small non-coding RNA that can be widely detected in plants,animal species and viruses. They regulate protein expression by repressing translation mRNA target at the post-transcriptional level, participating in the differentiation and development of tumor cells, as well as the occurrence and development of tumor, the change of the expression level microRNA plays an important role in the genesis and chemoresistance mechanism of NHL. Therefore, the intervening factitiously the expression level of microRNA in NHL through manufacturing antisense oligonucleotide (AMO) or using substitution of microRNA, changing the expression level of their target protein, and combining with the therapy of NHL, there will be an guiding significance in reversing the drug and radiation resistance of NHL, thus improving its poor prognosis. This article reviews the microRNAs closely related with drug and radiation resistance of NHL, and their potential targets. Furthermore, the specific role of these microRNAs in the genesis and chemoresistance mechanism of NHL are deeply elaborated.
