Expression characteristics of CD200 in acute myeloid leukemia and its clinical significance.
10.7534/j.issn.1009-2137.2014.06.006
- Author:
Xiao-Lu ZHANG
1
,
2
;
An-Li SHEN
3
;
Rui GUO
3
;
Yan WANG
3
;
Hai-Rong QIU
3
;
Chun QIAO
3
;
Hui YANG
3
;
Jian-Fu ZHANG
3
;
Jian-Yong LI
3
;
Yu-Jie WU
4
Author Information
1. Laboratory Center, Yuhuamgding Hospital of Shandong Yantai, Yantai 264000, Shangdong Province, China
2. Department of Hematology, The First Affiliated Hospital of Nanjing Medical University (Jiangsu Province People's Hospital), Nanjing 210029, Jiansu Province, China.
3. Department of Hematology, The First Affiliated Hospital of Nanjing Medical University (Jiangsu Province People's Hospital), Nanjing 210029, Jiansu Province, China.
4. Department of Hematology, The First Affiliated Hospital of Nanjing Medical University (Jiangsu Province People's Hospital), Nanjing 210029, Jiansu Province, China. E-mail: wuyujie123456@163.com.
- Publication Type:Journal Article
- MeSH:
Antigens, CD;
immunology;
Chromosome Banding;
Humans;
Immunophenotyping;
Karyotyping;
Leukemia, Myeloid, Acute;
diagnosis;
genetics;
immunology;
Oncogene Proteins, Fusion;
Prognosis
- From:
Journal of Experimental Hematology
2014;22(6):1531-1534
- CountryChina
- Language:Chinese
-
Abstract:
This study was aimed to investigate the relationship between expression of CD200 antigen and clinical characteristics in AML patients and to analyse the value of CD200 in evaluation of AML prognosis. The CD200 and immunophenotypes were detected by flow cytometry, the chromosome karyotypes were determined by R banding, the FISH was used to measure the AML1/ETO, PML/RARa and inv(16), and PCR technique was used to detect the fusion genes AML1/ETO and PML/RARα. The results showed that the positive rate of CD200 antigen expression in 54 patients was 57.4% (31/54), the CD200 antigen expression between sex and age of patients was no significant different (P > 0.05). There was significant difference of CD200 expression between CD34 and CD117 (P < 0.05), but the difference of CD200 expression in chromosome karyotypes was no significant difference(P > 0.05). Moreover, there was significant difference of CD200 expression in CD34 and CD117 of CBF positive AML patients (P < 0.05). It is concluded that the CD200 antigen expression in AML may associate with a poor prognosis of patients.
