Significance of chromosome 7 abnormalities in myeloid malignancies.
10.7534/j.issn.1009-2137.2014.06.044
- Author:
Wen-Hui SHI
1
;
Xiao LI
2
;
Chun-Kang CHANG
1
Author Information
1. Department of Hematology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiaotong University,Shanghai 200233, China.
2. Department of Hematology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiaotong University,Shanghai 200233, China. E-mail: lixiao3326@yahoo.com.cn.
- Publication Type:Journal Article
- MeSH:
Chromosome Deletion;
Chromosomes, Human, Pair 7;
Humans;
Leukemia, Myeloid;
genetics;
Myeloproliferative Disorders
- From:
Journal of Experimental Hematology
2014;22(6):1739-1743
- CountryChina
- Language:Chinese
-
Abstract:
Chromosome 7 abnormalities are the most common cytogenetic alterations found in myeloid malignancies. Myeloid malignancies exhibiting monosomy 7/del (7q) have been confirmed to associate with high susceptibility to infections, poor response to chemotherapy, and short survival time, so speculating that chromosome 7 has important tumor suppressor genes. Commonly deleted segments (such as 7q22) of chromosome 7 have been identified by FISH and other technologies. Genes (EZH2, MLL5, DOCK4, SAMD9L/SAMD9) located in commonly deleted segments of 7q have been cloned and characterized along with the advance of molecular biology.This review summaries the current advancement about myeloid malignancies associated with monosomy7/del(7q).
