Expression and Significance of PTPL1 in Hematological Malignancies.
10.7534/j.issn.1009-2137.2014.06.045
- Author:
Wen-Ming WANG
1
;
Jing WANG
1
;
Hong-Mei JING
2
Author Information
1. Department of Hematology, Peking University Third Hospital, BeiJing 100191, China.
2. Department of Hematology, Peking University Third Hospital, BeiJing 100191, China. E-mail: jinghm@yahoo.com.
- Publication Type:Journal Article
- MeSH:
Cell Movement;
Cell Survival;
Genes, Tumor Suppressor;
Hematologic Neoplasms;
genetics;
metabolism;
pathology;
Humans;
Protein Tyrosine Phosphatase, Non-Receptor Type 13;
genetics;
metabolism
- From:
Journal of Experimental Hematology
2014;22(6):1744-1747
- CountryChina
- Language:Chinese
-
Abstract:
PTPL1 is a protein with a predicted MW of 270 kD, and plays a major role in many cellular functions, including cell survival, proliferation, differentiation and motility. Evidence has demonstrated that PTPL1 is associated with tumor. Although many conflicting results suggested that PTPL1 has two contradictory effects (supressing or promoting ) on tumor, the real effect depends on the involved substrate and the cellular context. Expression of PTPL1 is low in lymphoma, while it is high in myeloid leukemia. PTPL1 has been regarded as a tumor suppressor in lymphoma, the methylation of PTPL1 promoter leads to gene expression reduced or disappeared, playing a lymphoma tumor suppressor role. This review focuses on PTPL1 domain and its interacting proteins, the relationship between PTPL1 and hematological malignancies.
