Inflammatory reaction and alterations of pulmonary surfactant in Pseudomonas Aeruginosa pneumonia in immunocompromised rats.
- Author:
Jieming QU
1
;
Zhuozhe LI
;
Lixian HE
;
Bo SUN
;
Xuehua CHEN
Author Information
1. Department of Pulmonary Medicine, Zhongshan Hospital, Institute of Respiratory Diseases, Fudan University, Shanghai 200032, China. jiemingc@online.sh.cn
- Publication Type:Journal Article
- MeSH:
Animals;
Bronchoalveolar Lavage Fluid;
chemistry;
microbiology;
Lipids;
analysis;
Lung;
microbiology;
Male;
Neutrophils;
physiology;
Pneumonia, Bacterial;
immunology;
metabolism;
Proteolipids;
analysis;
Pseudomonas Infections;
immunology;
metabolism;
Pulmonary Surfactant-Associated Protein A;
Pulmonary Surfactant-Associated Proteins;
Pulmonary Surfactants;
analysis;
Rats;
Rats, Sprague-Dawley
- From:
Chinese Medical Journal
2002;115(7):1099-1100
- CountryChina
- Language:English
-
Abstract:
Pulmonary surfactant ( PS ) compromises lipids and surfactant proteins (SP) and lines on the alveolar air-liquid interface. It can reduce surface tension, prevent alveoli from collapse and reduce alveoli edema by disaturated dipalmitoylphosphatidylcholine. It also modulates the pulmonary immunology by SP-A and SP-D. In this study,we established a rat model of immunocompromised host (ICH) with pulmonary infection of Pseudomonas aeruginosa (P. aeruginosa), then studied its pulmonary inflammatory reaction and analyzed the concentration of lipids and SP-A in bronchoalveolar lavage fluid (BALF) during infection.
