Klebsiella pneumoniae: epidemiology and analysis of risk factors for infections caused by resistant strains.
- Author:
Jiabin LI
1
;
Yilin MA
;
Zhongxin WANG
;
Xinzhi YU
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; Aged, 80 and over; Child; Child, Preschool; Drug Resistance, Bacterial; Female; Humans; Infant; Infant, Newborn; Klebsiella Infections; drug therapy; epidemiology; etiology; Klebsiella pneumoniae; drug effects; Male; Middle Aged; Risk Factors
- From: Chinese Medical Journal 2002;115(8):1158-1162
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo analyze the epidemiology of hospital and community-acquired infections caused by Klebsiella pneumoniae (K. pneumoniae) and risk factors for infections caused by resistant strains.
METHODSA retrospective observational study was performed to analyze the relationship between antimicrobial use and bacterial resistance.
RESULTSA K. pneumoniae infection was diagnosed in 0.47% of patients (169 of 36 179) admitted to the hospital between 1 March 1999 and 31 August 2000. Of the 169 isolates, 166 (98.2%) were resistant to at least one antimicrobial and 91.1% (154/169) to two or more antibiotics. 98% were resistant to ampicillin, 77% to piperacillin, 64% to cephalothin, 60% to ampicillin/sulbactam, 59% to cefoperazone, 57% to cefazolin, 55% to cefuroxime, 51% to TMP-SMZ, 51% to tobramycin, 50% to gentamicin, 49% to aztreonam, cefetaxime and ceftriaxone respectively, 47% to ceftazidime, 47% to cefepime, 46% to ciprofloxacin, 46% to ticarcillin/clavulanate, 44% to amikacin, 38% to cefoxitin, 22% to piperacillin/tazobactam, while all strains were tested susceptible to imipenem.
CONCLUSIONSPrior receipt of amtimicrobial therapy was significantly associated with infection caused by a resistant organism and most strains were resistant to multiple antibiotics.
