Cholinergic receptor activity after quinolinic acid caused cerebral injury in rats.
- Author:
Pingping ZUO
1
;
Pengyi LUO
;
Yanyong LIU
Author Information
- Publication Type:Journal Article
- MeSH: Alzheimer Disease; etiology; Animals; Brain; drug effects; Choline O-Acetyltransferase; metabolism; Disease Models, Animal; Learning; drug effects; Male; Memory; drug effects; Nicotine; metabolism; Quinolinic Acid; toxicity; Quinuclidinyl Benzilate; metabolism; Rats; Rats, Wistar; Receptors, Cholinergic; analysis; drug effects
- From: Chinese Medical Journal 2002;115(8):1175-1178
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo provide a useful biological index for clinical diagnosis of Alzheimer's disease (AD) by determination the functional changes in the central cholinergic nerve and their effects on the peripheral lymphatic system.
METHODSThe learning and memory impairment model was established through intraventricular injecting quinolinic acid (QA) repeatedly.
RESULTSThere was a significant decline of cholineacetyltransferase (ChAT) in cerebral cortex and hippocampus after QA injection. The significantly lower binding activities of acetylcholine muscarinic (M) and nicotinic (N) cholinergic receptors in the hippocampus and cortex in the QA group were found as compared with the sham-operated group (P < 0.01). Similar changes were found in the binding activities of M-and N-receptors on spleen lymphocytes.
CONCLUSIONCertain lesion of the central nervous system can be reflected in peripheral spleen lymphocytes, which may be an important reference to diagnose the changes of the central nervous system.
