Clinical characteristics and outcomes among pediatric patients hospitalized with pandemic influenza A/H1N1 2009 infection.
10.3345/kjp.2011.54.8.329
- Author:
Eun LEE
1
;
Ju Hee SEO
;
Hyung Young KIM
;
Shin NA
;
Sung Han KIM
;
Ji Won KWON
;
Byoung Ju KIM
;
Soo Jong HONG
Author Information
1. Department of Pediatrics, Asan Medical Center Children's Hospital, Seoul, Korea. sjhong@amc.seoul.kr
- Publication Type:Original Article
- Keywords:
H1N1;
Pneumonia;
Children;
Hospitalization
- MeSH:
Asthma;
Child;
Dyspnea;
Glucose;
Heart Diseases;
Hospitalization;
Humans;
Influenza, Human;
Korea;
Leukocyte Count;
Lymphocytes;
Pandemics;
Platelet Count;
Pneumonia;
Polymerase Chain Reaction;
Retrospective Studies;
Tertiary Care Centers
- From:Korean Journal of Pediatrics
2011;54(8):329-334
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: The purpose of this article is to describe the clinical and epidemiologic features and outcomes among children hospitalized with pandemic influenza A/H1N1 2009 infection. METHODS: We retrospectively reviewed the charts of hospitalized pediatric patients (<18 years) diagnosed with pandemic influenza A/H1N1 2009 infection by reverse-transcriptase polymerase chain reaction at a tertiary hospital in Seoul, Korea, between September 2009 and February 2010. RESULTS: A total of 72 children were hospitalized with pandemic influenza A/H1N1 2009 infection (median age, 6.0 years; range, 2 months to 18 years). A total of 40% had at least 1 underlying medical condition, including asthma (17%), malignancies (19%), and heart diseases (17%). Of the 72 patients, 54 (76%) children admitted with H1N1 infection showed radiographic alterations compatible with pneumonia. There was no significant difference in pre-existing conditions between pandemic influenza A/H1N1 infected patients with or without pneumonia. Children with pandemic influenza A/H1N1 pneumonia were more likely to have a lower lymphocyte ratio (P=0.02), higher platelet count (P=0.02), and higher level of serum glucose (P=0.003), and more commonly presented with dyspnea than did those without pneumonia (P=0.04). CONCLUSION: No significant differences in age, sex, or presence of preexisting conditions were found between children hospitalized with pandemic influenza A/H1N1 H1N1 influenza infection with pneumonia and those without pneumonia. Higher leukocyte count, higher glucose level, and a lower lymphocyte ratio were associated with the development of pandemic A/H1N1 2009 influenza pneumonia.
