Role of exocrine cells in pancreatic enhancement using Mn-DPDP-enhanced MR imaging.
- Author:
Jingshan GONG
1
;
Jianmin XU
;
Kangrong ZHOU
;
Kuntang SHEN
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Contrast Media; Dogs; Edetic Acid; analogs & derivatives; pharmacokinetics; Image Enhancement; Magnetic Resonance Imaging; Manganese; pharmacokinetics; Pancreas; anatomy & histology; metabolism; Pyridoxal Phosphate; analogs & derivatives; pharmacokinetics
- From: Chinese Medical Journal 2002;115(9):1363-1366
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo investigate role of exocrine cells in the pancreatic enhancement images at Manganese (II) N, N'-dipyridoxylethlenediamine-N, N'-diacetate 5, 5'-bisc (Mn-DPDP)-enhanced magnetic resonance (MR) imaging.
METHODSArtificial pancreatic leakage was constructed in six dogs using a fistula tube inserted into the duodenum papillae. Pancreatic juice was collected before and after intravenous infusion of 2 ml/kg of Mn-DPDP at a rate of 2 - 3 ml/min. The Mn content of pancreatic juice was measured by atomic absorption spectroscopy. T(1)-weighted spin-echo images and T(1)-weighted spoiled phase gradient-echo (SPGR) images were obtained prior and approximately 30 min after the administration of Mn-DPDP at 1.5T.
RESULTSThe Mn content of pancreatic secretion increased 60.47 +/- 21.83 micro g/dl after the administration of Mn-DPDP (t = 6.785, P < 0.01). The signal/noise ratio (S/N) of the pancreas increased 53 percent +/- 49 percent and 62 percent +/- 44% on T(1)W spin echo images and SPGR images, respectively.
CONCLUSIONSExocrine cells of the pancreas can absorb manganese and excrete it through the pancreatic juice. Exocrine cells play an important role in the enhancement of the pancreas in MR imaging with Mn-DPDP.
