Log-transformed plasma level of brain natriuretic peptide during the acute phase of Kawasaki disease is quantitatively associated with myocardial dysfunction.
10.3345/kjp.2011.54.8.340
- Author:
Sunhee BANG
1
;
Jeong Jin YU
;
Myung Ki HAN
;
Hong Ki KO
;
Sail CHUN
;
Hyung Soon CHOI
;
Young Hwue KIM
;
Jae Kon KO
;
In Sook PARK
Author Information
1. Division of Pediatric Cardiology, Department of Pediatrics, University of Ulsan College of Medicine, Seoul, Korea. pediatrist@medimail.co.kr
- Publication Type:Original Article
- Keywords:
Kawasaki disease;
Myocarditis;
Brain natriuretic peptide
- MeSH:
Alanine Transaminase;
Biomarkers;
Brain;
C-Reactive Protein;
Child;
Hemoglobins;
Humans;
Leukocyte Count;
Linear Models;
Mucocutaneous Lymph Node Syndrome;
Myocarditis;
Natriuretic Peptide, Brain;
Plasma;
Serum Albumin
- From:Korean Journal of Pediatrics
2011;54(8):340-344
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Brain natriuretic peptide (BNP) has been considered a biochemical marker for myocarditis in Kawasaki disease. We performed this study to determine its quantitative significance. METHODS: We attempted to correlate log-transformed BNP concentrations (log-BNP) and clinical, laboratory, and echocardiographic variables in 81 children with Kawasaki disease. Stepwise multiple linear regression analysis was used to determine the variables independently associated with log-BNP concentration. RESULTS: Serum C-reactive protein level (P<0.0001), serum alanine aminotransferase concentration (P=0.0032), white blood cell count (P=0.0030), and left ventricular mass index (P=0.0024) were positively related with log-BNP, and hemoglobin level (P<0.0001), serum albumin level (P<0.0001), Na+ concentrations (P<0.0001), left ventricular fractional shortening (P=0.0080), and peak early diastolic tissue velocity of the left ventricular basal lateral segment (P=0.0045) were negatively related to the log-BNP concentration. Multiple regression analysis showed that serum albumin concentration (R2=0.31, P=0.0098) and left ventricular mass index (R2=0.09, P=0.0004) were significantly associated with the log-BNP concentration. CONCLUSION: Elevated BNP levels during the acute phase of Kawasaki disease may be attributable to cardiac dysfunction associated with the increase in left ventricular mass, and log-BNP concentration may be a quantitative biochemical marker of myocarditis in Kawasaki disease.
