Successful Treatment of Hydroxychloroquine-Induced Recalcitrant Acute Generalized Exanthematous Pustulosis with Cyclosporine: Case Report and Literature Review.
- Author:
Basak YALCIN
1
;
Seray CAKMAK
;
Betul YILDIRIM
Author Information
- Publication Type:Case Report
- Keywords: Acute generalized exanthematous pustulosis; Cyclosporine; Hydroxychloroquine
- MeSH: Acute Generalized Exanthematous Pustulosis*; Aged; Cyclosporine*; Female; Humans; Hydroxychloroquine
- From:Annals of Dermatology 2015;27(4):431-434
- CountryRepublic of Korea
- Language:English
- Abstract: Acute generalized exanthematous pustulosis (AGEP) is a cutaneous reaction principally induced by drugs. Spontaneous resolution is observed in most patients. However, severe cases required systemic corticosteroid administration. Hydroxychloroquine, which is used to treat some dermatologic and rheumatologic diseases because of its anti-inflammatory and immunosuppressive effects, is an uncommon cause of AGEP. A 67-year-old female patient presented with severe AGEP due to hydroxychloroquine treatment. She was recalcitrant to supportive care and systemic corticosteroid treatment butwas successfully treated with cyclosporine. Hydroxychloroquine-induced AGEP occurs in women with underlying rheumatologic diseases, has a longer latent period, and has a severe course usually requiring systemic treatment.
