The effects of chronic rapid eye movement sleep deprivation on energy metabolism and FT3, FT4 level in serum of rats.
- Author:
Rong ZENG
1
;
Shu-li SHAO
;
Xin-jun XU
;
Wei-wei ZHANG
;
Da-lei SI
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Energy Metabolism; physiology; Male; Rats; Rats, Wistar; Sleep Deprivation; blood; metabolism; Sleep, REM; physiology; Thyroxine; blood; Time Factors; Triiodothyronine; analogs & derivatives; blood
- From: Chinese Journal of Applied Physiology 2010;26(1):105-108
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the effect of chronic rapid eye movement sleep deprivation on energy metabolism, FT3, FT4 in serum.
METHODSRapid eye movement sleep deprivation of rats were deprived by flower pot, and then the energy metabolism were detected. The FT3, FT4 level in serum was determined by radioimmunoassay kit.
RESULTSRats after sleep deprivation displayed food intake increased from (75.06 +/- 25.37)g/(d x kg) to (122.30 +/- 20.43)g/(d x kg), body weight substantially decreased from (360.89 +/- 43.01) g to (295.97 +/- 37.95) g, body temperature from (37.62 +/- 1.12) degrees C up to the first (39.00 +/- 0.87) degrees C and then reduced to (37.72 +/- 0.84) degrees C, the basal metabolism rate increased significantly from (1.69 +/- 0.36) mlO2/(g x h) to (2.40 +/- 0.09) mlO2/(g x h), compared with the control group( P < 0.05). Sleep deprivation also resulted significantly lower serum thyroxine levels in comparison with the control, serum free triiodothyronine (FT3) level reduced from (3.38 +/- 0.88) pmol/L to (2.38 +/- 0.83) pmol/L, then free thyroxine(FT4) decreased from (14.62 +/- 3.62) pmol/L to (8.26 +/- 2.80) pmol/L (P < 0.05).
CONCLUSIONRapid eye movement sleep deprivation can change energy metabolism remarkable, as well as the alteration of FT3, FT4 levels in serum.
