Effect of Ligusticum and its two main components on muscle atrophy in a hind limb unloaded rat model.
- Author:
Jin CAO
1
;
Yun-fang GAO
;
Kun LIU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Coumaric Acids; pharmacology; Drugs, Chinese Herbal; pharmacology; Extremities; Female; Hemorheology; Hindlimb Suspension; Ligusticum; chemistry; Muscle Fibers, Skeletal; drug effects; Muscular Atrophy; blood; etiology; prevention & control; Myosin Heavy Chains; metabolism; Pyrazines; pharmacology; Random Allocation; Rats; Rats, Sprague-Dawley
- From: Chinese Journal of Applied Physiology 2010;26(1):109-113
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the effects of Ligusticum and its two components (Sodium Ferulate and Ligustrazine as main efficacy components in Ligusticum for invigorating blood circulation) on muscle atrophy in a hind limb unloaded rat model.
METHODSThe tail-suspended rats were subjected to a 14-days disuse, immunohistochemistry and hemorheology were used to study the effects of medicines on soleus muscle.
RESULTSCompared with HLU+ W: (1) The CSA of soleus type I fibers in HLU + SfH and HLU+ TmpH increased by 37.3% and 39.4% respectively (P < 0.05). (2) Expression level of MHC II were inhibited in all treatment groups (P < 0.01). (3) Expression of MHC II in nuclear bag 2 fiber were altered from positive to negative. (4) The blood viscosity in low shear rates decreased obviously (P < 0.01), even near to control.
CONCLUSIONLigusticum and its two main efficacy components (Sodium Ferulate and Ligustrazine) can prevent soleus atrophy induced by disuse, and Sodium Ferulate and Ligustrazine in high dose showed most efficacy.
