Suitable oxygen concentration for rat model's hypoxic preconditioning.
- Author:
Ding-yu HU
1
;
Bo LI
;
Rong-ji DAI
;
Li-na GENG
;
Yu-lin DENG
Author Information
- Publication Type:Journal Article
- MeSH: Adaptation, Physiological; physiology; Animals; Body Weight; Hypoxia; physiopathology; Ischemic Preconditioning; Male; Oxygen; analysis; metabolism; Physical Endurance; physiology; Rats; Rats, Wistar
- From: Chinese Journal of Applied Physiology 2010;26(2):137-141
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the suitable oxygen concentration in hypoxic preconditioning.
METHODSShort-term and long-term intermittent hypoxia modes were designed and the effects of various oxygen concentrations on body weight, blood oxygen saturation, swimming capability were analyzed.
RESULTSThe rate of body weight gain in rat model decreased gradually when exposed to hypoxia environment for long time. When the concentration of oxygen changed from 15% to 8%, accompanied with the decreasing of oxygen concentration, a platform was observed in blood oxygen saturation of rat model after hypoxic preconditioning training. Rat swimming capability improved significantly. After trained in 10% hypoxia environment, the swimming capability of kunming mice improved obviously.
CONCLUSIONProper level of hypoxic preconditioning training could improve hypoxia tolerance and enhance the rat sport capability significantly. 15%-10% oxygen concentration range could be regarded as a helpful effective area for hypoxic preconditioning, 10% oxygen concentration might be the eligible concentration for hypoxic preconditioning training.
