Lymphocyte GRK2 expression of the very elderly with chronic heart failure.
- Author:
Wen-qian GAO
1
;
Jin-ling MA
;
Chun-guang HAN
;
Qiong WANG
;
Ping ZHU
;
Ting-shu YANG
Author Information
- Publication Type:Journal Article
- MeSH: Aged, 80 and over; Chronic Disease; G-Protein-Coupled Receptor Kinase 2; genetics; metabolism; Heart Failure; blood; physiopathology; Humans; Lymphocytes; metabolism; Male; RNA, Messenger; genetics; metabolism; Stroke Volume; physiology
- From: Chinese Journal of Applied Physiology 2010;26(2):207-209
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the correlation of lymphocyte G protein-coupled receptor kinases 2 (GRK2) expression of the very elderly with chronic heart failure (HF) and heart ejection fraction (EF).
METHODS16 elderly patients with chronic heart failure were divided into 2 groups as following: EF < 45% (n=7), EF > or = 45% (n=9); and health elderly as control (n=8). Lymphocytes were obtained from blood, reverse transcription polymerase chain reaction were used to measure GRK2 mRNA levels.
RESULTSLymphocyte GRK2 mRNA levels of EF < 45% group were higher than that of EF > 45% group, which were greater than that of control.
CONCLUSIONElevation of lymphocyte GRK2 levels in HF is associated with heart EF, lymphocytes may provide a surrogate for monitoring cardiac GRK2 in human HF.
