Effect of endogenous H2S on platelet L-Arg transport.
- Author:
Wen-zhuo DUAN
1
;
Yi-peng WANG
;
Hai-min GONG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Arginine; metabolism; Biological Transport; drug effects; Blood Platelets; drug effects; metabolism; Hydrogen Sulfide; metabolism; pharmacology; Male; Rats; Rats, Sprague-Dawley
- From: Chinese Journal of Applied Physiology 2010;26(2):234-236
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the effect of novel air neuromodulator H2S on platelet function of L-Arg transport for discussing H2S of effect on platelet function.
METHODSSaturate H2S solution as donate made rat rich platelet plasma and pre-incubation rat platelet with different density of H2S. To measure the velocity of L-Arg transport in platelet by radioactivity technique.
RESULTSAt different concentrations of H2S (6.25, 12.5, 25, 50, 100 micromol/L), the velocity of L-Arg transport was lower than that in control. H2S reduced rapidly the Vmax and velocity of L-Arg transport in platelet (P < 0.05) and this effect had no effect to Km.
CONCLUSIONH2S can affect platelet function by changing rapidly platelet L-Arg transport system function.
