The proarrhythmic effects of autoantibody against beta1 adrenergic receptor.
- Author:
Xiu-Rui MA
1
;
Jun-Li DUAN
;
Lin ZUO
;
Jin WANG
;
Zhong-Mei HE
;
Zi YAN
;
Rong-Hua ZHENG
;
Guang-Zhao YANG
;
Hui-Rong LIU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Arrhythmias, Cardiac; etiology; immunology; Autoantibodies; blood; immunology; Case-Control Studies; Female; Humans; Immunoglobulin G; blood; Male; Middle Aged; Rats; Receptors, Adrenergic, beta-1; immunology
- From: Chinese Journal of Applied Physiology 2010;26(3):257-260
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the distribution characteristics of autoantibody against beta1 adrenergic receptor (beta1 AR) in the sera of arrhythmia patients and whether the autoantibody could induce arrhythmia.
METHODSHealthy subjects and patients with arrhythmia or coronary artery disease were chosen. The autoantibody against beta1 AR in the sera was screened by enzyme-linked immunosorbent assay (ELISA). IgG in the positive autoantibody sera from arrhythmia patients were purified and administrated to normal rats; then the ECGs were dynamic monitored.
RESULTSThe positive rate of autoantibody against beta1 AR in arrhythmia patients was 52.8%, which was significantly higher than that in coronary heart disease group (24%, P < 0.01) and healthy people group (5%, P < 0.01), respectively. Moreover, the autoantibody against beta1 AR could lead to the occurring of arrhythmia in normal rats, most of which were ventricular arrhythmia.
CONCLUSIONIn the sera of arrhythmia patients, the autoantibody against beta1 AR has a high titer and it could lead to the arrhythmia of rats in vivo.
