Protective effects and pathogenesis of complex salvin miltiorrhiza on acute mercury poisoning in rabbits.
- Author:
You-Ling JING
1
;
Yan-Lei WANG
;
Dan-Dan YIN
;
Bo-Hai CAO
;
Wei ZHANG
;
Fei GENG
;
Na SUN
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Drugs, Chinese Herbal; pharmacology; therapeutic use; Female; Male; Mercury Poisoning; blood; drug therapy; Phenanthrolines; pharmacology; therapeutic use; Rabbits; Salvia miltiorrhiza
- From: Chinese Journal of Applied Physiology 2010;26(3):341-344
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study protective effect and pathogenesis of complex salvia miltiorrhiza (DanShen) on acute mercury poisoning in rabbits.
METHODSModels of acute mercury poisoning was made in rabbits. The effect of complex salvia miltiorrhiza on blood urea nitrogen (BUN), copper-protein (CP), lactate dehydrogenase (LDH), acid phosphatase (ACP) and the malondialdehyde (MDA) in plasma, superoxide dismutase (SOD) in erythrocyte and MDA, SOD in tissues homogenate were observed.
RESULTSThe administration of complex salvia miltiorrhiza after mercury injection 0.5 h and 9.5 h, decreased BUN, CP, MDA, LDH and ACP, and prevented the reduction of SOD. Compared with mercury poisoning group, the difference was statistical significant (P < 0.05, P < 0.01).
CONCLUSIONIt is suggested that acute mercury poisoning may result in renal damage but also multiple organ tissues, and complex salvia miltiorrhiza possesses protective effect, through stabilized membranes.
