The relationship between silicosis and the polymorphism of HLA-DRB1 *, DQB1 * genes.
- Author:
Baojun YUAN
1
;
Zhixin ZHANG
;
Hongfen LI
;
Yanhe CHANG
;
Zhizhong LIU
;
Jimin ZOU
;
Wei LI
;
Xiaoyan SHAN
Author Information
- Publication Type:Journal Article
- MeSH: Gene Frequency; Genetic Predisposition to Disease; HLA-DQ Antigens; genetics; HLA-DQ beta-Chains; HLA-DR Antigens; genetics; HLA-DRB1 Chains; Humans; Polymerase Chain Reaction; Polymorphism, Genetic; Silicosis; genetics
- From: Chinese Journal of Industrial Hygiene and Occupational Diseases 2002;20(2):93-96
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the relation between the susceptibility to silicosis and the polymorphism of HLA-DRB1 *, DQB1 * genes in Chinese Hans.
METHODSHLA-DRB1 * and DQB1 * gene polymorphism were tested in 48 silicosis patients and 100 normal controls by using polymerase chain reaction of sequence-specific primers (PCR-SSP).
RESULTSThe allele frequencies of DRB1 * 1401 and DQB1 * 05 in silicosis patients were significantly higher than those in normal controls (chi 2 = 5.61, P = 0.0066, RR = 17.40; chi 2 = 10.70, P = 0.0011, RR = 3.81, respectively), while the allele frequency of DRB1 * 09 was significantly lower in silicosis patients than that in controls (chi 2 = 5.70, P = 0.0187, RR = 0.21). There was a significant difference between the patient group and control group.
CONCLUSIONHLA-DRB1 * 1401 and DQB1 * 05 may be the susceptible genes and HLA-DRB1 * 09 the protection gene of silicosis, both susceptibility and protection may be related to HLA-DR gene locus. The joint action of allele genes may affect the pathogenesis of silicosis.
