The relationship between hemoglobin adducts of trinitrotoluene and exposed level.
- Author:
Wenjia SONG
1
;
Yawen WANG
;
Huifang YAN
;
Shuguang LENG
;
Yeping GU
;
Yuying LIU
;
Yuxin ZHENG
Author Information
- Publication Type:Journal Article
- MeSH: Environmental Monitoring; methods; Hemoglobins; metabolism; Humans; Occupational Exposure; Skin; drug effects; Trinitrotoluene; metabolism
- From: Chinese Journal of Industrial Hygiene and Occupational Diseases 2002;20(3):189-191
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the biomarkers for monitoring trinitrotoluene (TNT) exposure, the relationship between TNT hemoglobin adducts and TNT exposed level.
METHODHemoglobin adducts (4A-Hb and 2A-Hb) were determined by GC-MS in 25 TNT exposed workers. TNT exposed level was evaluated by determining skin contaminated and inhaled TNT levels. The correlation between hemoglobin adducts level and TNT exposed level was analyzed.
RESULTSThere was a correlation between total TNT exposure level, especially skin exposure level, and 4A-Hb or 2A-Hb content. No significant difference was found between the slopes and intercepts of lin ear equation of (4A-Hb) vs TNT exposed level and linear equation of (4A-Hb +2A-Hb) vs TNT exposed level (P > 0.05).
CONCLUSIONSkin contamination is the major role of TNT exposure. TNT exposed level can be evaluated by determining the content of both 4A-Hb and 2A-Hb, and 4A-Hb is more suitable for monitoring TNT exposure.
