Evaluation of urinary ortho-cresol as biological monitoring indicator of occupational exposure to toluene.
- Author:
Yaxian MI
1
;
Daili LIU
;
Zhihua LI
;
Jianguo LI
;
Yi LUO
;
Jian HU
Author Information
- Publication Type:Journal Article
- MeSH: Chromatography, High Pressure Liquid; Cresols; urine; Environmental Monitoring; methods; Humans; Occupational Exposure; Toluene; metabolism
- From: Chinese Journal of Industrial Hygiene and Occupational Diseases 2002;20(3):200-202
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the feasibility of urinary ortho-cresol levels as a biological monitoring indicator for toluene exposure.
METHODSEstablish pre-column derivation HPLC method to detect ortho-cresol levels in urine of human body. Ortho-cresol levels in urine of workers non-exposed and exposed to toluene was examined using this pre-column derivation HPLC method, and exposure assessment was conducted.
RESULTSIt was shown that urinary ortho-cresol level in exposed workers was (2.61 +/- 1.94) mg/L, higher than those of control group [(0.32 +/- 0.23) mg/L, P < 0.001]. Urinary ortho-cresol level in exposed workers at the end of a workshift was higher than those before exposure to toluene, and also was correlated with the concentration of toluene to which individual exposed(r = 0.6295, P < 0.01).
CONCLUSIONUrinary ortho-cresol as a biological monitoring indicator for toluene exposure is feasible.
