Acute fluoroacetamide poisoning with main damage to the heart.
- Author:
Jieming LIN
1
;
Chaoqiang JIANG
;
Jianping OU
;
Gang XIA
Author Information
- Publication Type:Journal Article
- MeSH: Acute Disease; Alanine Transaminase; blood; Creatine Kinase; blood; Electrocardiography; drug effects; Fluoroacetates; poisoning; Heart; drug effects; Humans; Hydroxybutyrate Dehydrogenase; blood; L-Lactate Dehydrogenase; blood
- From: Chinese Journal of Industrial Hygiene and Occupational Diseases 2002;20(5):344-346
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the heart damage in 10 patients with acute fluoroacetamide poisoning.
METHODSMonitoring serum activities of myocardial enzymes [creatine kinase (CK), asparate aminotransferase (AST), lactate dehydrogenase(LDH) and hydroxybutyrate dehydrogenase(HBDH)] and recording ECG on these 10 patients were performed during the period of their hospitalization. In the mean while, 24 hour dynamic ECG were also recorded and analysed using GP7000L Holter.
RESULTS(1) Urinary fluorine ion concentrations were increased in 9 patients before therapy and in all these 10 patients during therapeutic period. (2) The activities of serum CK in 2 patients and that of serum HBDH in one patient were increased before therapy. However, the serum activities of one or more than one myocardial enzymes were increased in all these 10 patients during therapeutic period. (3) Four patients had abnormal change of ECG before therapy and 5 patients during therapeutic period. (4) 24 hour dynamic ECG records showed that there were heart electrical alternans in 9 patients. One patient had wandering pacemaker and 6 patients had arythmia.
CONCLUSIONFluoroacetamide may cause obvious heart damage, and also heart electrical alternation.
