Renal dysfunction in workers exposed to arsenic and cadmium.
- Author:
Feng HONG
1
;
Tai-yi JIN
;
Guo-dong LU
;
Zheng-yu YIN
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Albuminuria; chemically induced; Arsenic; toxicity; urine; Cadmium; toxicity; urine; Dose-Response Relationship, Drug; Female; Humans; Kidney; drug effects; Male; Middle Aged; Occupational Exposure; beta 2-Microglobulin; urine
- From: Chinese Journal of Industrial Hygiene and Occupational Diseases 2003;21(6):432-436
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo examine the nephrotoxicity induced caused by combined effect of arsenic and cadmium in exposed workers.
METHODSUrinary cadmium and arsenic were used as the exposure biomarkers of cadmium and arsenic. Urinary beta2-microglobulin (Ubeta2-MG), albumin (UALB) and N-acetyl-beta-D-glucosaminidase (UNAG) were measured as the effective biomarkers of tubular and glomerular dysfunction induced by cadmium and arsenic.
RESULTSThe combination of cadmium and arsenic induced more severe renal injury than that caused by either of the chemicals given alone. There were positive correlations and significant dose-effect among the concentrations of urinary cadmium, arsenic and levels of Ubeta2-MG, UALB, UNAG (P<0.05, P<0.01).
CONCLUSIONCadmium combined with arsenic may have additive effect on renal dysfunction in workers exposed to arsenic and cadmium.
