The level of serum tumor necrosis factor-alpha and epidermal growth factor in patients with medicament-like dermatitis by trichloroethylene and its clinical significance.
- Author:
Sen-hua LI
1
;
Ze-ming ZENG
;
Guan-chao LAI
;
Lai-yu LI
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Drug Eruptions; blood; Epidermal Growth Factor; blood; Female; Humans; Male; Receptor, Epidermal Growth Factor; analysis; Trichloroethylene; toxicity; Tumor Necrosis Factor-alpha; analysis
- From: Chinese Journal of Industrial Hygiene and Occupational Diseases 2003;21(6):437-439
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the level of tumor necrosis factor alpha (TNF-alpha) and epidermal growth factor (EGF) in patients with medicament-like dermatitis by trichloroethylene (DMLT).
METHODSUsing radioimmunoassay methods, serum TNF-alpha, EGF were measured in 39 patients with DMLT and in 20 controls.
RESULTSThe levels of serum TNF-alpha, EGF in patients with DMLT [(0.278 +/- 0.092) ng/L, (6.71 +/- 2.28) microg/L, respectively] were significantly higher than those of the controls [(0.128 +/- 0.029) ng/L, (4.31 +/- 1.13) microg/L respectively, P<0.05, P<0.01].
CONCLUSIONThe increased levels of serum TNF-alpha, EGF in patients with DMLT may be related to the following causes: (1) Trichloroethylene and its metabolite may irritate the macrophagocyte and monocyte in human body to release TNF-alpha into blood stream; (2) Severe damage of epithelial tissue in patients with DMLT may promote more EGF synthesis to accelerate the regeneration and repair of epithelial tissue.
