Function of tumor suppressor p53 and its role in antiviral immunity.
- Author:
Wen-Jun YAN
1
;
Kai-Bao WU
;
Zhi-Yong MA
Author Information
1. Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai 200241, China. yanwenjun01@163.com
- Publication Type:Journal Article
- MeSH:
Animals;
Cell Physiological Phenomena;
Humans;
Immunity;
Inflammation;
immunology;
metabolism;
virology;
Tumor Suppressor Protein p53;
genetics;
metabolism;
Viruses;
immunology
- From:
Chinese Journal of Virology
2012;28(4):462-470
- CountryChina
- Language:Chinese
-
Abstract:
Tumor suppressor p53, known as 'the guardian of the genome', has the ability to prevent the emergence of transformed cells by the induction of cell cycle arrest and apoptosis. Otherwise, there were researches about the function of p53, such as NDA repair, regulating metabolism and maternal reproduction in recent years. Furthermore, there was a new function for p53 in antiviral apoptosis mentioned in the research, Integration of interferon-alpha/beta signaling to p53 responses in tumour suppression and antiviral defense. In order to define the antiviral function of p53, many target genes has been defined, such as IRF9, IRF5, ISG15 and TLR3. All of these implied there must be a complex mechanism for role of p53 in antiviral innate immunity, adaptive immunity and inflammation.
