Preliminary studying the hypoglycemic mechanism of smilax glabra
- Author:
Xuan Ngoc Nguyen
- Publication Type:Journal Article
- Keywords:
Traditional medicine
- MeSH:
Hypoglycemic Agents;
Mice
- From:Journal of Medical Research
1999;10(2):37-42
- CountryViet Nam
- Language:Vietnamese
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Abstract:
The hypoglycemic effect of rhizomes of SG was investigated in the previous publication in normal mice. This study attempts to explain its mechanism of action. The streptozotocin-induced diabetic mice (STZ 300 mg/kg/ip) one of the model of insulin-dependent diabetes mellitus (IDDM) with hypoinsulinemia, either the methanol extract of rhizomes of SG Roxb - Smilacaceae or the tolbutamid did not affect the blood sugar. However, while tolbutamid couldn't decrease epinephrine - induced hyperglycemia in mice, SG partially suppressed this one. From these results, it is suggested that SG reduce the blood sugar by an extra - pancreas mechanism
