Virological characterization of influenza B virus in mainland China during 2011-2012.
- Author:
Wei-Juan HUANG
1
;
Min-Ju TAN
;
Yu LAN
;
Yan-Hui CHENG
;
Zhao WANG
;
Xi-Yan LI
;
Jun-Feng GUO
;
He-Jiang WEI
;
Yao-Yao CHEN
;
Ning XIAO
;
Bin LIU
;
Hong-Tao SUI
;
Xiang ZHAO
;
Da-Yan WANG
;
Yue-Long SHU
Author Information
1. Chinese National Influenza Center, National Institute for Viral Disease Control and Prevention, China CDC, Beijing, China. huangweijuan@cnic.org.cn
- Publication Type:Journal Article
- MeSH:
China;
Humans;
Influenza B virus;
classification;
genetics;
immunology;
Influenza Vaccines;
genetics;
immunology;
Phylogeny;
Time Factors
- From:
Chinese Journal of Virology
2013;29(1):32-38
- CountryChina
- Language:Chinese
-
Abstract:
In order to understand the prevalence and variation of influenza B viruses, the antigenic and genetic characteristics of influenza B viruses circulating in Mainland China during April, 2011 to March, 2012 were analyzed. The results showed the B Victoria lineage viruses were much more prevalent than B Yamagata lineage during this period, phylogenetic analysis showed vast majority of Victoria lineage viruses belong to genetic group 1, intra-clade reassortant between HA1 and NA gene was identified in a minor proportion of the viruses. 72.8% of the B/Victoria-lineage viruses were antigenically closely related to the vaccine strain B/Brisbane/60/2008. B Yamagata component was not included in the trivalent influenza vaccine in China during the study period, however vast majority of B Yamagata lineage viruses were antigenically and genetically closely related to the representative virus B/Hubei-Wujiagang/158/2009(97.8%) and B/Sichuan-Anyue/139/2011(85.2%) in China, reassortant between HA1 and NA was not identified in B Yamagata lineage viruses. Overall, the predominant circulating influenza B viruses in 2011-2012 season in China were matched by current influenza vaccine and the selected representative viruses were proved to represent the antigenic and genetic characteristics of the circulating viruses.
