Emerged Pdm09 influenza virus increased purifying selection of seasonal H1N1 influenza virus.
- Author:
Yu LAN
1
;
Wei-Juan HUANG
;
Hong-Tao SUI
;
Xi-Yan LI
;
Xiang ZHAO
;
Ming LI
;
Yao-Yao CHEN
;
Jun-Feng GUO
;
Yan-Hui CHENG
;
Min-Ju TAN
;
Zhao WANG
;
Ning XIAO
;
He-Jiang WEI
;
Da-Yan WANG
;
Yue-Long SHU
Author Information
1. Chinese National Influenza Center, National Institute for Viral Disease Control and Prevention, China CDC, Beijing 102206, China. lanyu@cnic.org.cn
- Publication Type:Journal Article
- MeSH:
China;
Humans;
Influenza A Virus, H1N1 Subtype;
classification;
genetics;
isolation & purification;
Influenza, Human;
virology;
Phylogeny;
Seasons;
Selection, Genetic
- From:
Chinese Journal of Virology
2013;29(2):143-147
- CountryChina
- Language:Chinese
-
Abstract:
Pdm09 virus outbreak occurred in Mainland China in May 2009, a few months later, the prevalence of seasonal H1N1(sH1N1) influenza virus that already circulated in human for tens of years began to decline and disappeared afterwards. To identify the reason for the rapid decline of sH1N1 in mainland China, we sequenced the HA1 of sH1N1 during 2006-2011, and then analyzed the selective pressure in different phases. Our results showed before Pdm09 outbreak, the omega value was 0. 36 while after Pdm09 outbreak the omega value was 0. 28 and significant difference (t test, P<0. 05) was identified. We concluded that sH1N1 obtained stronger purifying selection after Pdm09 outbreak in China. This might one of the major reasons causing the disappearance of sH1N1 in human.
