Progress in development of influenza virus-like particles.
- Author:
Sheng-Qiang GE
1
;
Zhi-Liang WANG
Author Information
1. China Animal Health and Epidemiology Center, Qingdao 266032, China. Shengqiang_Ge@163.com
- Publication Type:Journal Article
- MeSH:
Animals;
Humans;
Influenza Vaccines;
genetics;
immunology;
Influenza, Human;
immunology;
virology;
Orthomyxoviridae;
genetics;
immunology;
physiology;
Viral Proteins;
genetics;
immunology;
Virion;
genetics;
immunology;
physiology;
Virus Assembly
- From:
Chinese Journal of Virology
2013;29(2):224-232
- CountryChina
- Language:Chinese
-
Abstract:
Virus-like particles (VLPs) are composed of multiple copies of one or more expressed recombinant viral structural proteins which spontaneously assemble into particles upon expression. VLPs are non infectious because they assemble without incorporating genetic material. VLPs have structural characteristics and antigenicity similar to the parental virus because they mimick the wild-type virus structure. Hence, they are recognized readily by the immune system which induces strong anti-viral immune responses to stop virus infection. VLPs have therefore shown dramatic effectiveness as candidate vaccines and diagnostic reagent for virus. Here, in order to provide reference to the research of influenza VLPs, we reviewed the current research progress of influenza VLPs, and discussed the characteristics associated with producing VLPs for influenza virus.
