Research progress in the structure and fuction of Orthopoxvirus host range genes.
- Author:
Zheng LIU
1
;
Ying LIU
;
Yi-Ming SHAO
Author Information
1. China Center for Disease Control and Prevention, Beijing 102206, China. 285022750@qq.com
- Publication Type:Journal Article
- MeSH:
Cell Line;
Cowpox virus;
genetics;
immunology;
pathogenicity;
physiology;
Genetic Vectors;
Host Specificity;
genetics;
Orthopoxvirus;
genetics;
immunology;
pathogenicity;
physiology;
Signal Transduction;
Vaccines, Synthetic;
immunology;
Vaccinia virus;
genetics;
immunology;
pathogenicity;
physiology;
Viral Proteins;
genetics;
metabolism;
Viral Vaccines;
immunology;
Virulence
- From:
Chinese Journal of Virology
2013;29(4):437-441
- CountryChina
- Language:Chinese
-
Abstract:
Orthopoxvirus vector has a broad prospect in recombinant vaccine research, but the rarely severe side-effect impedes its development. Vaccinia virus and Cowpox virus of Orthopoxvirus have broad host range, and they have typical host range genes as K1L, CP77 and C7L. These three genes affect host range of Vaccinia virus, disturb the cell signaling pathways, suppress immune response and are related to virulence.
