Expression of transforming growth factor-β(1) and Ki-67 nuclear antigen in salivary gland mucoepidermoid carcinoma.
- Author:
Jun-Ping LAO
1
;
Ju-Feng CHEN
Author Information
- Publication Type:Journal Article
- MeSH: Adenoma, Pleomorphic; metabolism; pathology; Adolescent; Adult; Carcinoma, Mucoepidermoid; metabolism; pathology; Cell Differentiation; Female; Humans; Ki-67 Antigen; metabolism; Male; Middle Aged; Salivary Gland Neoplasms; metabolism; pathology; Transforming Growth Factor beta1; metabolism; Young Adult
- From: Chinese Journal of Stomatology 2011;46(1):20-23
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the expression and significance of transforming growth factor-β(1) (TGF-β(1)) and Ki-67 nuclear antigen in salivary gland mucoepidermoid carcinoma.
METHODSThe expression of TGF-β(1) and Ki-67 nuclear antigen in 20 cases of salivary gland pleomorphic adenoma and 45 cases of mucoepidermoid carcinoma were detected by the streptavidin-peroxidase immunohistochemical method.
RESULTSExpression of TGF-β(1) (39/45) and Ki-67 nuclear antigen (43/45) in mucoepidermoid carcinoma was significantly higher than in pleomorphic adenoma (P < 0.05). TGF-β(1) expression was significantly higher in moderately/poorly differentiated mucoepidermoid carcinoma (16/16) than that in well differentiated mucoepidermoid carcinoma (23/29) and pleomorphic adenoma (12/20) (P < 0.05), but not different between well differentiated mucoepidermoid carcinoma (6/23) and pleomorphic adenoma (8/12) (P > 0.05). The expression of Ki-67 was increased with the increment of TGF-β(1) expression in mucoepidermoid carcinoma (P < 0.05).
CONCLUSIONSThe high expression of TGF-β(1) may play an important role in cell differentiation and malignant proliferation of mucoepidermoid carcinoma.
