Expression of transforming growth factor-β1 and Ki-67 nuclear antigen in salivary gland mucoepidermoid carcinoma
10.3760/cma.j.issn.1002-0098.2011.01.008
- VernacularTitle:转化生长因子β1及Ki-67核抗原在涎腺黏液表皮样癌中的表达和意义
- Author:
Jun-Ping LAO
1
;
Ju-Feng CHEN
Author Information
1. 中山大学附属佛山市第一人民医院
- Keywords:
Carcinoma,mucoepidermoid;
Transforming growth factor betal;
Antigens,nuclear
- From:
Chinese Journal of Stomatology
2011;46(1):20-23
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression and significance of transforming growth factor-β1 (TGF-β1)and Ki-67 nuclear antigen in salivary gland mucoepidermoid carcinoma. Methods The expression of TGF-β1 and Ki-67 nuclear antigen in 20 cases of salivary gland pleomorphic adenoma and 45 cases of mucoepidermoid carcinoma were detected by the streptavidin-peroxidase immunohistochemical method. Results Expression of TGF-β1 (39/45) and Ki-67 nuclear antigen (43/45) in mucoepidermoid carcinoma was significantly higher than in pleomorphic adenoma ( P ＜ 0.05 ). TGF-β1 expression was significantly higher in moderately/poorly differentiated mucoepidermoid carcinoma ( 16/16 ) than that in well differentiated mucoepidermoid carcinoma (23/29) and pleomorphic adenoma (12/20) ( P ＜ 0.05 ), but not different between well differentiated mucoepidermoid carcinoma (6/23) and pleomorphic adenoma (8/12)(P ＞ 0.05 ). The expression of Ki-67 was increased with the increment of TGF-β1 expression in mucoepidermoid carcinoma (P ＜ 0.05 ). Conclusions The high expression of TGF-β1 may play an important role in cell differentiation and malignant proliferation of mucoepidermoid carcinoma.
