Visual imaging for buccal carcinoma with near-infrared fluorescent quantum dots in vivo
10.3760/cma.j.issn.1002-0098.2011.03.002
- VernacularTitle:近红外荧光量子点对颊癌可视化活体成像研究
- Author:
Kai YANG
1
;
Yu-An CAO
;
Zhi-Gang LI
;
Xiao-Qiang L(U)
;
Cheng ZHAO
;
Jia YANG
Author Information
1. 重庆医科大学附属第一医院
- Keywords:
Carcinomas,squamous cell;
Quantum dots;
Early diagnosis
- From:
Chinese Journal of Stomatology
2011;46(3):134-138
- CountryChina
- Language:Chinese
-
Abstract:
Objective To examine the in vivo visual imaging of buccal carcinoma with the nearinfrared fluorescent quantum dots. Methods The U14 cells were labeled by endocytosis with QD800 (U14/QD800) which was linked with cell-penetrating peptide. Different number of U14/QD800 was injected under the buccal mucosa of nude mice and Kunming mice separately and imaged at different time to detect the in vivo sensitivity and dynamic imaging of U14/QD800. Results The minimum number of U14/QD800 cells which could be detected by in vivo imaging system was 1 × 104 in nude mice's cheek and 1 × 105 in Kunming mice's. The time for visual imaging of 1 × 104, 1 × 105 and 1 × 106 U14/QD800 cells in nude mice was 3, 7 and 16 d separately, and 3 and 10 d separately in Kunming mice. Conclusions Due to its strong tissue penetration, near-infrared fluorescent quantum dots have great prospects in cancer early diagnosis, visual observation and individual treatment.
