Malignant pleomorphic adenoma of salivary gland with subtype of the malignant component classified as non-specific adenocarcinoma: a clinicopathologic study of 65 cases.
- Author:
Jing LI
1
;
Jiang LI
;
Li-Zhen WANG
;
Lei LI
;
Han-Bing FU
Author Information
- Publication Type:Journal Article
- MeSH: Adenocarcinoma; pathology; Adenoma, Pleomorphic; pathology; Adult; Aged; Aged, 80 and over; Female; Humans; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Invasiveness; Neoplasm Staging; Retrospective Studies; Salivary Gland Neoplasms; pathology; Salivary Glands; pathology; Salivary Glands, Minor; pathology; Young Adult
- From: Chinese Journal of Stomatology 2011;46(6):355-359
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo analyze the clinicopathologic features of salivary malignant pleomorphic adenoma (MPA) (the subtype of the malignant component was classified as non-specific adenocarcinoma).
METHODSThe clinical and pathological characteristics of 115 salivary gland tumors histologically diagnosed as MPA were analyzed.
RESULTSIn all the 65 MPA cases, there were 58 male and 7 female patients, and the mean age was 57 years (from 23 to 83). Sixty-one tumors were located in major salivary glands, and 4 in minor. Histologically the malignant components of 39 tumors were high-grade, 14 intermediate-grade, and 12 low-grade. Thirty-seven tumors were invasive carcinoma, 13 minimally invasive, and 15 non-invasive. The high-grade tumors had positive correlation with the invasive carcinomas (P < 0.05). The invasive carcinomas had positive correlation with TNM clinical stage (P < 0.05). The invasive carcinoma and the high-grade tumor had correlation with cervical lymph node metastasis (P < 0.05).
CONCLUSIONSNon-specific adenocarcinoma are the most common malignant subtype in MPA. The invasive and the high-grade types are more likely to metastasize to cervical lymph node.
