Effect of fetus hypobaric hypoxia on NMDA receptor of hippocampus neurons.
- Author:
Hui HUANG
1
;
Huai-zhen RUAN
;
Xiao-tang FAN
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Cell Hypoxia; Fetus; physiopathology; Hippocampus; cytology; physiopathology; In Situ Hybridization; Intracranial Hypotension; physiopathology; N-Methylaspartate; metabolism; Neurons; pathology; Patch-Clamp Techniques; RNA, Messenger; genetics; Rats; Receptors, N-Methyl-D-Aspartate; metabolism
- From: Chinese Journal of Applied Physiology 2002;18(4):321-323
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo study the effect of fetus hypobaric hypoxia on the number and channel character of NMDA receptor of hippocampus neurons.
METHODSUse in situ hybridization and patch-clamp techniques.
RESULTSAfter hypobaric hypoxia the number of NMDA mRNA positive neurons was decreased, the open probability of NMDA receptor was reduced, the open time constant was decreased, the close time constant was increased.
CONCLUSIONHypobaric hypoxia may change the development of NMDA receptor in fetus rat, then maybe effect learning and memory.
