The effect of cyclooxygenase-2 on dopaminergic neurons in substantia nigra of Parkinson's disease mice induced by MPTP.
- Author:
Dong-dong LI
1
;
Wan-qin ZHANG
;
Zhe-hui FENG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Cyclooxygenase 2; deficiency; Male; Mice; Mice, Inbred C57BL; Neurons; pathology; Parkinson Disease; pathology; Substantia Nigra; pathology
- From: Chinese Journal of Applied Physiology 2002;18(4):333-336
- CountryChina
- Language:Chinese
-
Abstract:
AIM AND METHODSUsing Strain C57/BL of COX-2 deficient mice, the effect of Cyclooxygenase-2 (COX-2) on dopaminergic neurons in substantia nigra of Parkinson's disease (PD) mice induced by intraperitoneal injections of MPTP-HCl were investigated by immunocytochemistry(ICC) .
RESULTSWe found that the mortality in COX-2 heterozygous mice is much lower than that in wild type mice (P < 0.01) after injection of MPTP (30 mg/kg/day). The result of semiquantitative immunocytochemical staining showed that the number of tyrosine hydroxylase (TH) immunoreactive neurons in the substantia nigra pars compacta (SNc) declined more significantly in MPTP-treated wild type mice than that in COX-2 heterozygotes mice (P < 0.01).
CONCLUSIONCOX-2 may be related with lesion of dopaminergic neurons in the SNc of PD.
