Protective effect of magnesium on hippocampal neurons damage induced by glutamic acid.
- Author:
Feng-ling HUANG
1
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Animals, Newborn; Cell Survival; Cells, Cultured; Glutamic Acid; toxicity; Hippocampus; cytology; Magnesium; pharmacology; Neurons; drug effects; Rats; Rats, Sprague-Dawley
- From: Chinese Journal of Applied Physiology 2002;18(4):340-342
- CountryChina
- Language:Chinese
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Abstract:
AIMTo investigate the effect of magnesium ion (Mg2+) on neuronic damage induced by 0.1 mmol/L glutamic acid.
METHODSThe neurons isolated from hippocampus in rats were cultured for 6-9 days, and then randomly divided into three groups: A. medium alone. B. medium + glutamic acid. C. medium+ Mg2+, and + glutamic acid (30 min late).
RESULTS(1) DAs compared with A group, the survival rate of hippocampal neurons in B group was remarkably decreased in dose dependent mauner. (2) In contrast to B group, when the concentration of Mg2+ was lower, the survival rates of hippocampal neurons in C group was significantly increased.
CONCLUSIONMg2+ in lower concentration could protect hippocampal neurons from damage induced by glutamic acid.
