The change of cholesterol level and Na+ -K+ -ATPase activity of erythrocyte membrane in early stage of severe burn patients.

Author: Da-lun LV ¹ ; Fan CUI ; Xiao-ning LI
Author Information

1. Department of Burns, 2.Laboratoy, Affiliated Hospital of Wannan Medical College, Wuhu 241001, China.
Publication Type:Journal Article
MeSH: Adult; Burns; metabolism; Case-Control Studies; Cholesterol; chemistry; Erythrocyte Membrane; chemistry; Erythrocytes; metabolism; Female; Humans; Male; Middle Aged; Sodium-Potassium-Exchanging ATPase; metabolism
From: Chinese Journal of Applied Physiology 2002;18(4):391-393
CountryChina
Language:Chinese
Abstract:
AIMTo study the relationship between erythrocyte filtration index (EFI) and cholesterol and Na+ -K+ -ATPase activity of erythrocyte membrane in early stage of severe burns.
METHODSThe EFI was measured by means of percolation, the erythrocyte membrane cholesterol level was measured by means of chemically modified electrode, and the membrane Na+ -K+ -ATPase activity by means of detection of Pi.
RESULTSIn early stage of severe burns, the cholesterol level and Na+ -K -ATPase activity of erythrocyte membrane were always higher than those of control group (P < 0.01), but the EFI was lower than that of control group (P < 0.01). The cholesterol level and Na+ -K+ -ATPase activity of the erythrocyte membrane were negative correlation with EFI (r cho= -0.871, r ATPase = -0.801, P < 0.01) nospectively.
CONCLUSIONThe cholesterol level and Na+ -K+ -ATPase activity of erythrocyte membrane play a key role in the change of EFI.