Protective effect of GABA against hypoxic injury in rat hippocampal slices.

Author: Tong ZHAO ¹ ; Fu-Zhuang WANG ; Yan-Hua HUANG ; Hang YAO ; Zhen-Wei LIU ; Ming FAN
Author Information

1. Department of Neurobiology, Institute of basic Medical Sciences, Academy of Millitary Medical Sciences, Bejing 100850, China.
Publication Type:Journal Article
MeSH: Animals; Chloride Channels; physiology; Evoked Potentials; Hippocampus; physiopathology; Hypoxia; drug therapy; physiopathology; In Vitro Techniques; Male; Neuroprotective Agents; therapeutic use; Rats; Rats, Wistar; gamma-Aminobutyric Acid; therapeutic use
From: Chinese Journal of Applied Physiology 2003;19(1):16-19
CountryChina
Language:Chinese
Abstract:
AIMTo study the mechanism of protective effect of GABA against hypoxic injury in rat hippocampal slices.
METHODSThe hippocampal slices from adult rats and extracellular recording technique were used to observe the effect of GABA on the evoked population spikes in rat hippocampal slices after hypoxia in vitro.
RESULTSGABA can significantly delay the disappearance of PV, but have no effect on PS. When the receptor antagonist of GABA (bicuculline) and the inhibitor of Cl- channel (NPPB) were given, the protect effect could be suppressed.
CONCLUSIONGABA increases hypoxic tolerance of hippocampal slices. The mechanism of the effect of GABA may be involved in the elevation of chloride influx through GABA receptor.