Effect of losartan on produce of sera autoantibodies to angiotensin II-1 receptor in renovascular hypertension rats.
- Author:
Jian-Ming ZHI
1
;
Zhong-Bao LIU
;
Xiang-Ying JIAO
;
Ying-Xu LIU
;
Rong-Rui ZHAO
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Autoantibodies; biosynthesis; blood; Hypertension, Renovascular; blood; immunology; Losartan; pharmacology; Male; Rats; Rats, Wistar; Receptors, Angiotensin; immunology
- From: Chinese Journal of Applied Physiology 2003;19(1):43-46
- CountryChina
- Language:Chinese
-
Abstract:
AIM AND METHODSThe effects of losartan (after operation 2 week to 10 week, 5 mg/kg d ig) on generation of AT1R-AA in sera were observed during development of hypertension in rats. The renovascular hypertension (RVH) model was established by two-kidney one-clip method, a synthetic peptide corresponding to amino acid sequence 165-191 of the second extracellular loop of the angiotensin II-1 receptor (AT1R) was used as antigen, SA-ELISA were used to examine sera AT1R autoantibody (AT1R-AA).
RESULTSThe frequencies and titres of AT1R-AA after operation one week rats were significantly increased (P < 0.05). The treatment with losartan not only inhibited structural and functional changes, but also the frequencies and titres of AT1R-AA was significantly lower (P < 0.05) than RVH group.
CONCLUSIONIt is suggested that the losartan significantly inhibits generation of the AT1R-AA.
