Effect of anions and anion channel blockers on vascular tone in rat aorta.
- Author:
Heng MA
1
;
Jian-ming PEI
;
Yue-min WANG
;
An-gang YANG
;
Shi-sheng ZHOU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Anions; metabolism; Aorta; drug effects; physiology; In Vitro Techniques; Ion Channels; antagonists & inhibitors; Male; Muscle Contraction; drug effects; physiology; Muscle, Smooth, Vascular; drug effects; physiology; Norepinephrine; pharmacology; Rats; Rats, Sprague-Dawley
- From: Chinese Journal of Applied Physiology 2003;19(2):105-108
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo investigate the action of anions and anion channel blockers in the regulation of vascular contraction induced by norepinephrine (NE).
METHODSNE-induced contraction was observed in rat aorta by using routine blood vascular perfusion in vitro.
RESULTSThe anion channel blockers niflumic acid (NFA) and 5-nitro-2-(3-phenoxylpropylamino)-benzoic acid (NPPB) produced inhibitory effects on NE-evoked contractions in the aorta. NE-induced contraction was not significantly changed after the extracellular Na+ was replaced by choline, in contrast, the vascular was relaxed when the extracellular Cl- was replaced by glutamate. Moreover, the vasoconstriction induced by NE was further enhanced with the replacement of the extracellular Cl- by Br-, which was still sensitive to either NFA or NPPB.
CONCLUSIONSAnion channels play an important role in the regulation of blood vascular tone, which may be responsible for the salt-sensitivity hypertension.
