The protective effects of IPC on isolated myocardial ischemia/reperfusion injury in rats.
- Author:
Xia CAO
1
;
Xin-quan GU
;
Shi-jie YANG
;
Hui-qing ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Female; Heart; physiopathology; Ischemic Preconditioning, Myocardial; methods; Male; Myocardial Reperfusion Injury; prevention & control; Rats; Rats, Wistar
- From: Chinese Journal of Applied Physiology 2003;19(2):114-116
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo investigate the protective effects and mechanism of IPC on myocardial ischemia/reperfusion injury.
METHODSEffects of IPC on arrhythmia and coronary blood flow and the release of AST, CPK, LDH, SOD and LFO at different time after ischemia/reperfusion injury in rat Langendorff hearts were studied.
RESULTSIPC decreased the release of AST, CPK and LDH and increased myocardial SOD activity and decreased LPO level. IPC also inhibited ischemia/reperfusion arrhythmias and increased coronary blood flow.
CONCLUSIONThe results showed that IPC had well protective effects on myocardial ischemia/reperfusion injury.
