Role of serotonergic neurons in dorsal raphe nuclei in regulation of sleep.
- Author:
Le-zhang ZHAO
1
;
Gong-liang ZHANG
;
Jun GAO
;
Jing-xing ZHANG
;
Ming-kui ZHONG
;
Jing ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Action Potentials; Animals; Male; Neurons; physiology; Polysomnography; Raphe Nuclei; physiology; Rats; Rats, Sprague-Dawley; Serotonin; physiology; Sleep; physiology
- From: Chinese Journal of Applied Physiology 2003;19(2):175-178
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo investigate the roles of serotonergic neurons in dorsal raphe nuclei (DRN) in sleep.
METHODSStereotaxic, microinjection and polysomnography (PSG) were used in the experiment.
RESULTSMicroinjection of L-glutanate (L-Glu) into the DRN decreased slow wave sleep (SWS) and paradoxical sleep (PS), and increased wake (W). Microinjection of kainic acid (KA) and p-chlorophenylalanine (PCPA) respectively into the DRN, SWS and PS were promoted, and W was reduced.
CONCLUSIONSerotonergic neurons in dorsal raphe nuclei involved in the regulation of sleep. Sleep was reduced when the serotonergic neurons were excited, and when the neurons were inhibited. sleep was increased
