Capsaicin-sensitive afferent fibers and endogenous NO mediate the gastric acid secretion and gastric mucosal blood flow in intragastric distention in rats.
- Author:
Luo GU
1
;
Chang-dong YAN
;
Jun DU
;
Su-ping TIAN
;
Dong-sheng LI
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Capsaicin; pharmacology; Gastric Acid; secretion; Gastric Dilatation; metabolism; Gastric Juice; secretion; Gastric Mucosa; blood supply; Male; NG-Nitroarginine Methyl Ester; Neurons, Afferent; drug effects; Nitric Oxide; physiology; Rats; Rats, Sprague-Dawley
- From: Chinese Journal of Applied Physiology 2003;19(2):193-196
- CountryChina
- Language:Chinese
-
Abstract:
AIM AND METHODSBy hydrogen gas clearance technique to measure gastric mucosal blood flow (GMBF) and a high dose of capsaicin to ablate the capsaicin-sensitive afferent fibers, the roles of capsaicin-sensitive afferent fibers and endogenous NO in the gastric acid secretion and hyperemic response to intragastric distention were studied in rats.
RESULTS(1) There was an increase in acid secretion associated with the increase in GMBF to intragastric distention. (2) Pretreatment with a high dose of capsaicin to ablate afferent fibers completely abolished the GMBF and partially inhibited the acid secretion during the intragastric distention. (3) The increase in GMBF to intragastric distention was completely blocked by pretreatment with L-NAME, whereas the acid secretion was significantly attenuated.
CONCLUSIONCapsaicin-sensitive afferent fibers and endogenous NO are involved in the increases of gastric acid secretion and GMBF.
