Influence of astragalus and zinc sulfate on the viscosity in erythrocyte membrane during intestinal ischemia - reperfusion(I/R) injury.
- Author:
Chun-Xiu ZHAO
1
;
You-Ling JING
;
Lian-Fei CHAI
;
Guo-Xian DUAN
;
Hong-Jie LI
;
Shuo-Sen ZHANG
;
He-Qin CUI
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Astragalus Plant; Blood Viscosity; Drugs, Chinese Herbal; pharmacology; Erythrocyte Membrane; drug effects; Female; Intestines; blood supply; pathology; Lipid Peroxidation; Male; Malondialdehyde; analysis; Oxidoreductases; analysis; Rabbits; Reperfusion Injury; metabolism; pathology; Superoxide Dismutase; analysis; Zinc Sulfate; pharmacology
- From: Chinese Journal of Applied Physiology 2003;19(3):213-215
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo study the influence of astragalus and zinc sulfate on the viscosity in erythrocyte membrane during intestinal I/R and their mechanism of action.
METHODSModels of rabbits intestinal I/R injury were made. The effect of astragalus and zinc sulfate on the viscosity and malondialdehyde (MDA) in erythrocyte membrane, superoxide dismutase (SOD) in erythrocyte, oxidase (XO) in plasma and MDA tissues homogenate were observed.
RESULTSThe administration of astragalus and zinc sulfate decreased viscosity and MDA and XO, prevented the reduction of SOD, and alleviated I/R injury.
CONCLUSIONLipid peroxidation injury of the erythrocyte membrane was one of the pathogenesis of I/R injury, and astragalus and the zinc sulfate possessed effects of anti-lipid peroxide, stabilized erythrocyte membrane, increased red blood cell deform ability and raised microcircular perfusion.
