Correlation between blood T-cell receptor rearrangement excision circles levels and severe infection in children with acute lymphoblastic leukemia.
- Author:
Cheng-Juan LUO
1
;
Hua JIANG
;
Jing CHEN
;
Jia-Le DAI
;
Xiao-Yu SHEN
;
Hui-Liang XUE
;
Jing-Yan TANG
;
Chang-Ying LUO
;
Ci PAN
;
Shu-Hong SHEN
;
Min ZHOU
;
Long-Jun GU
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Child; Child, Preschool; DNA, Circular; blood; Female; Gene Rearrangement, T-Lymphocyte; Humans; Infant; Male; Precursor Cell Lymphoblastic Leukemia-Lymphoma; drug therapy; genetics; immunology
- From: Chinese Journal of Contemporary Pediatrics 2011;13(6):466-470
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVEThis study quantitatively examined signal joint T-cell receptor rearrangement excision circles (sjTRECs) levels in peripheral blood of children with acute lymphoblastic leukemia (ALL) at different stages in order to evaluate the role of sjTRECs in predicting severe infection postchemotherapy.
METHODSsjTRECs levels in peripheral blood were measured by fluorescent quantitation-polymerase chain reaction in 30 children with newly diagnosed ALL, 36 children with ALL who accepted chemotherapy but were not infected, 30 children with ALL who had severe infection after chemotherapy, and 50 normal children.
RESULTSBlood sjTRECs levels in the normal group (394 ± 270 copies/103 MNC) were significantly higher than those in the other three groups (P<0.05). Blood sjTRECs levels in the chemotherapy group without infection (96 ± 78 copies/103 MNC) were significantly lower than those in the newly diagnosed ALL group (210 ± 219 copies/103 MNC) (P<0.05). The chemotherapy group with severe infection showed the lowest blood sjTRECs levels (48 ± 40 copies/103 MNC) in the four groups.
CONCLUSIONSThe measurement of blood sjTRECs levels might be helpful for predicting the occurrence of severe infection postchemotherapy in children with ALL.
