Mobilization and collection of autologous peripheral blood stem cells by CIE or IEV protocol in children with malignant solid tumors.
- Author:
Yi ZHANG
1
;
Wei-Ling ZHANG
;
Dong-Sheng HUANG
;
Yi-Ping YANG
;
Xiao-Chao LIU
;
Yi-Ping WU
Author Information
- Publication Type:Journal Article
- MeSH: Antineoplastic Combined Chemotherapy Protocols; administration & dosage; pharmacology; Child; Child, Preschool; Epirubicin; administration & dosage; Etoposide; administration & dosage; Female; Granulocyte Colony-Stimulating Factor; pharmacology; Hematopoietic Stem Cell Mobilization; adverse effects; methods; Humans; Ifosfamide; administration & dosage; Male; Neuroblastoma; therapy; Peripheral Blood Stem Cell Transplantation; Recombinant Proteins; Rhabdomyosarcoma; therapy; Transplantation, Autologous
- From: Chinese Journal of Contemporary Pediatrics 2011;13(6):471-474
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVEAutologous peripheral blood stem cell transplantation (APBSCT) is an important method for treatment of malignant solid tumors in children. The mobilization and collection of blood stem cells is crucial for APBSCT. This study aimed to evaluate the clinical efficacy of mobilization and collection of blood stem cells by CIE or IEV chemotherapy protocol in APBSCT in children with neuroblastoma (NB) or rhabdomyosarcoma.
METHODSThe protocols of CIE (cisplatin, etoposide) and IEV (vincristine, dosfamide, etoposide) were used as mobilization chemotherapy in 8 cases of NB with stage IV and 3 cases of rhabdomysacoma with stage III, respectively. The results of the mobilization of blood stem cells were observed.
RESULTSOf the 11 cases, mononuclear cells (MNC) and CD34+ cells were successfully collected and the volume of MNC and CD34 averaged (5.55 ± 1.43)× 10(8)/kg and (4.88 ± 2.48) × 10(6)/kg, respectively. No severe complications were observed during the mobilization and collection. A rapid hemopoietic reconstitution was observed in 10 children after APBSCT. One with NB out of the 10 children died of left heart failure 32 days after APBSCT. Others (9 cases) showed a nearly normal result of routine peripheral blood test 60 days after APBSCT.
CONCLUSIONSCIE or IEV protocol is effective and safe for the mobilization and collection of peripheral blood stem cells in children with NB or rhabdomysacoma.
