Chromosome analysis in 92 children with congenital mental retardation.
- Author:
Fang WANG
1
;
Yao YANG
;
Xiao YANG
;
Chun-Zhi WANG
;
Xi-Yu HE
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Child; Child, Preschool; Chromosome Aberrations; Female; Genetic Testing; Humans; Infant; Intellectual Disability; genetics; Karyotyping; Male; Sex Chromosome Aberrations
- From: Chinese Journal of Contemporary Pediatrics 2011;13(8):651-653
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the chromosome karyotypes in children with mental retardation.
METHODSThe peripheral blood lymphocytes from 92 children with congenital mental retardation were cultured and analysed by the G-band technique.
RESULTSOf the 92 cases, 43 cases (47%) showed chromosome abnormalities. Autosomal abnormalities were found in 35 cases (38%) and sex chromosome abnormalities were found in 8 cases (9%). A novel abnormal karyotype 45, XX, psu dic (11;9) (p15;p24) was found in a child.
CONCLUSIONSChromosome abnormalities may be important cytogenetic factors for congenital mental retardation. Cytogenetic chromosome karyotypic analysis appears to be an important method for genetic screening of congenital mental retardation.
