Intestinal inflammation-induced child growth failure: immunologic and endocrine mechanisms.
- Author:
Jing-Qiu MA
1
;
Xiao-Yang SHENG
Author Information
1. Department of Child and Adolescent Health Care, Shanghai Jiao Tong University School of Medicine, China.
- Publication Type:Journal Article
- MeSH:
Bone Development;
Cytokines;
physiology;
Enteritis;
complications;
Growth Disorders;
etiology;
Human Growth Hormone;
physiology;
Humans;
Somatomedins;
physiology
- From:
Chinese Journal of Contemporary Pediatrics
2011;13(9):767-771
- CountryChina
- Language:Chinese
-
Abstract:
Faltering linear growth is commonly encountered in children with intestinal inflammation. Growth hormone (GH) and insulin-like growth factor-1 (IGF-1) are important regulators of postnatal longitudinal bone growth. Inhibition of GH/IGF axis will result in growth failure in young children. Pro-inflammatory cytokines such as interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) abnormally increase in children with intestinal inflammation, and may affect linear growth both systemically and locally at the level of the growth plate though disturbing the GH/IGF axis.
