Expression of c-kit and Cx43 in neonates with spontaneous gastric perforation.
- Author:
Li-Na XIA
1
;
Zhi-Qiang WANG
;
Zong-Min WANG
;
Pu ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Connexin 43; analysis; Female; Humans; Infant, Newborn; Interstitial Cells of Cajal; pathology; Male; Proto-Oncogene Proteins c-kit; analysis; Rupture, Spontaneous; Stomach; chemistry; Stomach Rupture; congenital; metabolism; pathology
- From: Chinese Journal of Contemporary Pediatrics 2011;13(10):787-789
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the clinical significance of interstitial cell of Cajal (ICC) in spontaneous neonatal gastric perforation by examining the expression of c-kit and Cx43 in neonates with this disorder.
METHODSThe gastric specimens of 19 cases of neonatal gastric perforation from 2001 to 2010 and 8 cases of accidental death without digestive tract malformations (control) were collected. Immunohistochemical staining was employed to examine the expression of c-kit and Cx43 (immunomarkers of ICCs) in gastric tissues.
RESULTSThe muscular layer of the stomach wall became thinner or deficient in the gastric perforation group. C-kit and Cx43 positive cells in gastric tissues decreased significantly in the gastric perforation group compared with those in the control group (P＜0.01).
CONCLUSIONSThe development of spontaneous neonatal gastric perforation is associated with the decreased quantity of ICCs and damaged gap junction structure of the stomach wall.
